Modeling Mutations in CYP Proteins
Start Date
April 2026
Location
2nd floor - Library
Abstract
Cytochrome P450 enzymes or CYP proteins are a group of proteins responsible for catalyzing the reactions involved in drug metabolism. Mutations in a protein’s sequence can alter the functionality of the protein as well as it’s structure, whether the result is positive or negative. Mutations in CYP proteins can cause drug binding to either be weakened or strengthened, which in turn affects how an individual responds to drugs or medications. This project will employ computer-based programs and bioinformatics to detect and characterize mutations within the Cytochrome P450 enzymes. The research aims to specify which mutations are more or less likely to influence a change in enzyme functionality. We will be comparing and aligning these findings to the ones described in The Pharmacogenomics Journal 2022, 22:284-293 by Zhou and Lauschke. The paper details the spread of the mutations throughout specific CYP proteins. The goal of the project is to gain a better comprehension about how genetic variation can influence overall drug metabolism and degradation
Modeling Mutations in CYP Proteins
2nd floor - Library
Cytochrome P450 enzymes or CYP proteins are a group of proteins responsible for catalyzing the reactions involved in drug metabolism. Mutations in a protein’s sequence can alter the functionality of the protein as well as it’s structure, whether the result is positive or negative. Mutations in CYP proteins can cause drug binding to either be weakened or strengthened, which in turn affects how an individual responds to drugs or medications. This project will employ computer-based programs and bioinformatics to detect and characterize mutations within the Cytochrome P450 enzymes. The research aims to specify which mutations are more or less likely to influence a change in enzyme functionality. We will be comparing and aligning these findings to the ones described in The Pharmacogenomics Journal 2022, 22:284-293 by Zhou and Lauschke. The paper details the spread of the mutations throughout specific CYP proteins. The goal of the project is to gain a better comprehension about how genetic variation can influence overall drug metabolism and degradation
