Aminopeptidase sequence similarity of gut microbiome bacteria that differ in pancreatic cancer and healthy control patients
Start Date
April 2024
Location
2nd floor - Library
Abstract
Pancreatic cancer is an aggressive form of cancer with a high mortality rate. Previous literature has linked the enzyme Aminopeptidase N as a potential target for chemotherapy since increased production of the enzyme is linked with increased spread of cancer. In addition, previous research has shown the gut microbiome bacterial composition differs between pancreatic cancer patients and healthy patients. Genera of gut microbiome bacteria identified to be more abundant in pancreatic cancer patients include Prevotella, Veillonella, Klebsiella, Selenomonas, and Enterobacter (Ren et al., 2017). Genera of gut microbiome bacteria identified to be reduced in pancreatic cancer patients as compared to healthy controls include Dorea, Butyricicoccus, Anaerostipes, Blautia, and Coprococcus (Ren et al., 2017). BioCyc was used to identify amino acid sequences of aminopeptidase for a representative species of each genera, and Clustal Omega was used to complete multiple sequence alignments to identify similarity. There is no underlying similarity between the aminopeptidase amino acid sequences of the five identified genera more abundant in pancreatic cancer gut microbiomes, as well as no underlying similarity between aminopeptidase amino acid sequences of the five identified genera less abundant in pancreatic cancer gut microbiomes.
Aminopeptidase sequence similarity of gut microbiome bacteria that differ in pancreatic cancer and healthy control patients
2nd floor - Library
Pancreatic cancer is an aggressive form of cancer with a high mortality rate. Previous literature has linked the enzyme Aminopeptidase N as a potential target for chemotherapy since increased production of the enzyme is linked with increased spread of cancer. In addition, previous research has shown the gut microbiome bacterial composition differs between pancreatic cancer patients and healthy patients. Genera of gut microbiome bacteria identified to be more abundant in pancreatic cancer patients include Prevotella, Veillonella, Klebsiella, Selenomonas, and Enterobacter (Ren et al., 2017). Genera of gut microbiome bacteria identified to be reduced in pancreatic cancer patients as compared to healthy controls include Dorea, Butyricicoccus, Anaerostipes, Blautia, and Coprococcus (Ren et al., 2017). BioCyc was used to identify amino acid sequences of aminopeptidase for a representative species of each genera, and Clustal Omega was used to complete multiple sequence alignments to identify similarity. There is no underlying similarity between the aminopeptidase amino acid sequences of the five identified genera more abundant in pancreatic cancer gut microbiomes, as well as no underlying similarity between aminopeptidase amino acid sequences of the five identified genera less abundant in pancreatic cancer gut microbiomes.
